The Hebrew and Greek that is transliterated as «Issachar» in English is translated in Spanish Sign Language with a sign that signifies «donkey» referring to Genesis 49:14. (Source: Steve Parkhurst)
«Issachar» in Spanish Sign Language, source: Sociedad Bíblica de España
For more information on translations of proper names with sign language see Sign Language Bible Translations Have Something to Say to Hearing Christians .
See also strong(-boned) donkey.
More information on Issachar and the Tribe of Issachar .