Exegesis:
hoti ho huios men tou anthrōpou … poreuetai ‘for the Son of man goes (his way).’ Despite hoti the clause offers no explanation of v. 21. Rather it reaffirms the truth of the divine necessity of Jesus’ suffering which might, perhaps, be doubted after the revelation that one of the twelve was to deliver up Jesus. men is not followed by the usual de, instead of which the subsequent clause is introduced by the stronger plēn. This lends to the first clause of the verse almost the force of a concessive protasis, e.g. ‘though it remains true that the Son of man goes (his way).’
kata to hōrismenon poreuetai .’.. goes (his way) in accordance with what has been determined,’ hence, ‘goes his determined, or, appointed way,’ referring to the fact rather than to the manner of Jesus’ death.
horizō ‘to determine,’ ‘to appoint,’ ‘to decree.’ The agent is God.
plēn ouai tō anthrōpō ekeinō ‘but, woe to that man.’ For plēn and ouai cf. on 6.24.
di’ hou paradidotai ‘through whom he is handed over.’ The present tense suggests that the handing over is already under way.
Translation:
Goes, or, ‘goes his way’ can often have the sense of ‘to pass away’; if not, one may have to say, ‘goes to his death’ (Tzeltal), “will die” (Good News Translation).
As it has been determined, or, ‘in accordance with the (or, God’s) decree,’ ‘as God put it beforehand concerning him’ (Sranan Tongo); or, ‘which is what God has decided beforehand.’
Woe, see on 6.24.
By whom he is betrayed, preferably, ‘who is handing him over, or, delivering him up.’
Quoted with permission from Reiling, J. and Swellengrebel, J.L. A Handbook on the Gospel of Luke. (UBS Handbook Series). New York: UBS, 1971. For this and other handbooks for translators see here . Make sure to also consult the Handbook on the Gospel of Mark for parallel or similar verses.

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