12:21a They helped David against the raiders,

(Contemporary English Version🙂 They fought on his side when enemy troops attacked.

They helped David fight against bad men who were going around the country and stealing things from people. (English Easy-to-Read Version)
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They helped David to fight against other armies,

12:21b for they were all mighty men of valor

All these men of Manasseh were brave soldiers. (English Easy-to-Read Version)
-or-
because they all were brave/virtuous soldiers.

12:21c and commanders in the army.

David made them leaders in his army.
-or-
And they became officers in David’s army. (Easy English Bible)

12:21:a-c (combined)

They were brave/virtuous warriors and able commanders in David’s army. They assisted David when he fought against the band of raiders at Ziklag.

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