16:9a because a great door for effective work has opened to me,

A wide door of opportunity has opened up for me to do good work,
-or-
I will stay here because there are many people who want to believe in the word I preach.

16:9b even though many oppose me.

(New International Version) and there are many who oppose me.

and many people are against me.
-or-
Also there are many people who do not want me to preach.

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