1:21a For since in the wisdom of God the world through its wisdom did not know Him,

For God in his wisdom ⌊decided that⌋ wise people cannot know God by means of their own wisdom.
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For God very wisely made it impossible for people to know him ⌊fully⌋ through their own clever thoughts.
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For God wisely ⌊decided that⌋ this world’s people would not be able to know/understand him ⌊personally/fully⌋ through their own clever thoughts/ideas.

1:21b God was pleased through the foolishness of what was preached to save those who believe.

It pleased God to save those people who believe ⌊the good news⌋. ⌊He saves them⌋ through the foolish ⌊message that we⌋ preach.
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It pleased God to save ⌊from punishment⌋ those who believe ⌊the good news⌋. He used the foolish message that we preach ⌊to do this⌋.
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It pleased God to save those people who believe ⌊the message⌋ that we preach/announce. Some consider this message to be foolish.

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