“The word ‘offend’ as a translation of the Greek skandalizó seems to cause all sorts of trouble for translators. The difficulty is that the meaning of this word covers such a wide area. The basic meaning of the Greek is ‘to cause to stumble by putting some impediment in the way.’ The present central meaning of English ‘offend’ is often quite different. In some languages there is no metaphorical value in a translation ‘to cause someone to stumble.’ If the language permits no such metaphor, the translator should not attempt to force it. In Highland Totonac, the metaphor ‘to show the wrong road to’ is used in a manner almost exactly parallel to the Greek idiom.” (Source: Nida 1947)
In San Blas Kuna the translation is “spoil the heart” (source: Claudio and Marvel Iglesias in The Bible Translator 1951, p. 85ff.).
See also fall away, stumble.